Figures
Fungipod protrusions on human immature dendritic cells.
Dendritic cells use the C-type lectin CD206 (Mannose Receptor) to recognize fungal cells. Neumann and Jacobson (doi:10.1371/journal.ppat.1000760) report the discovery of the fungipod, a novel protrusive structure triggered on dendritic cells after CD206 engagement by yeast. Fungipods are long, conical motile structures with abundant F-actin, as shown in this projection image of a phalloidin-stained dendritic cell bearing several fungipods. Both S. cerevisiae and some pathogenic Candida species induce fungipods.
Image Credit: Aaron K. Neumann and Ken Jacobson, University of North Carolina, Chapel Hill
Citation: (2010) PLoS Pathogens Issue Image | Vol. 6(2) February 2010. PLoS Pathog 6(2): ev06.i02. https://doi.org/10.1371/image.ppat.v06.i02
Published: February 26, 2010
Copyright: © 2010 Neumann, Jacobson. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Dendritic cells use the C-type lectin CD206 (Mannose Receptor) to recognize fungal cells. Neumann and Jacobson (doi:10.1371/journal.ppat.1000760) report the discovery of the fungipod, a novel protrusive structure triggered on dendritic cells after CD206 engagement by yeast. Fungipods are long, conical motile structures with abundant F-actin, as shown in this projection image of a phalloidin-stained dendritic cell bearing several fungipods. Both S. cerevisiae and some pathogenic Candida species induce fungipods.
Image Credit: Aaron K. Neumann and Ken Jacobson, University of North Carolina, Chapel Hill