Figures
Expression of the VP16 promoter following zosteriform spread of herpes simplex virus type 1.
Following infection of mice on the cornea, virus is transported through axons to the trigeminal ganglia, where it can travel through axons back to body surfaces (shown here as blue staining cells in the hair follicles of the mouse whisker pad). VP16 is normally expressed late and packaged into virions, where it initiates viral gene expression in the infected cell. Once latency is established in neurons, the stochastic derepression of VP16 is required to initiate viral reactivation (see Thompson et al.,doi:10.1371/journal.ppat.1000352).
Image Credit: Nancy M. Sawtell, Cincinnati Children's Hospital Medical Center
Citation: (2009) PLoS Pathogens Issue Image | Vol. 5(3) March 2009. PLoS Pathog 5(3): ev05.i03. https://doi.org/10.1371/image.ppat.v05.i03
Published: March 27, 2009
Copyright: © 2009 Nancy M. Sawtell. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Following infection of mice on the cornea, virus is transported through axons to the trigeminal ganglia, where it can travel through axons back to body surfaces (shown here as blue staining cells in the hair follicles of the mouse whisker pad). VP16 is normally expressed late and packaged into virions, where it initiates viral gene expression in the infected cell. Once latency is established in neurons, the stochastic derepression of VP16 is required to initiate viral reactivation (see Thompson et al.,doi:10.1371/journal.ppat.1000352).
Image Credit: Nancy M. Sawtell, Cincinnati Children's Hospital Medical Center