Fig 1.
A schematic illustration depicting how metabolites influence the epigenetic regulation of latent EBV episomes.
Multiple metabolic pathways exist, but only those relevant to this Pearls are shown. Abbreviations: SAM, S-adenosylmethionine; α-KG, α-ketoglutarate; TCA cycle, tricarboxylic acid cycle; MTs, methyltransferases; TET, ten-eleven translocation dioxygenases; JMJD, Jumonji C domain containing histone demethylases; HATs, histone acetyltransferases; ACLY, ATP citrate lyase; Me, methylation; Ac, acetylation. This figure was created using biorender.
Fig 2.
A schematic illustration showing how virus-induced tryptophan catabolism elevates kynurenine levels, leading to suppression of effector T cells and activation of regulatory T cells (Tregs), thereby promoting immunotolerance during long-term infection in vivo.
Abbreviations: IDO1, indoleamine 2,3 dioxygenase 1; EBNA2, Epstein–Barr virus nuclear antigen 2; AhR, aryl hydrocarbon receptor. This figure was created using biorender.