Table 1.
Summary of regulators referenced in the manuscript.
Fig 1.
Overview of global and specific regulators controlling virulence factor expression in K. pneumoniae.
Major virulence factor loci are indicated by boxes, and transcriptional regulatory proteins shown as blue ovals for core genome-encoded regulators, and purple ovals for accessory genome-encoded regulatory proteins. Green or red arrows indicate transcriptional activation or repression, respectively. A subset of global regulators including H-NS, the Rcs system, and Fur are involved in regulation of multiple factors. Created in Biorender.
Fig 2.
Plasmid–chromosome cross talk in regulating virulence factor expression in hypervirulent K. pneumoniae.
The canonical hypervirulence plasmid contains both the Salmochelin and rmp loci. IroP is expressed from downstream of the salmochelin synthesis genes, and suppresses expression of the chromosomal Type 3 fimbrial genes when iron levels are low. The rmp locus encodes three proteins that collectively act to increase capsule transcription and promote a change in capsule structure. Both rmp and the capsule loci are repressed by Fur in high iron conditions, and are regulated by the Rcs system. In addition, the rmpA promoter is activated by the core genome-encoded regulator ArgR. Created in Biorender.