Fig 1.
The immunopathogenesis of sepsis involves both pro-inflammatory and anti-inflammatory determinants. These two opposing responses converge, leading to sepsis and potentially death. Created with Biorender.com. https://BioRender.com/rrncrc9.
Table 1.
Comparative overview of sepsis characteristics by age.
Fig 2.
From a heterogeneous population of sepsis, the concept of endotypes allows the definition of subgroups based on shared pathophysiological characteristics. The goal is to enable earlier diagnosis and propose targeted therapies to improve patient prognosis. Created with Biorender.com. https://BioRender.com/3gj0f10.
Fig 3.
Schematic integration of pre-sepsis in the pathogenesis of sepsis.
The pre-sepsis phase (B) corresponds to the host response occurring immediately after contact with a microorganism (A). The intensity and duration of this response vary depending host susceptibility and pathogen virulence (blue dots). When the equilibrium point (red dot) is surpassed, sepsis occurs (C), characterized by organ failure. Created with Biorender.com. https://BioRender.com/km9u12y.