Fig 1.
Schematic representation of trypanosomatid model organisms. (A) Overview of Trypanosoma brucei procyclic form organelles and cellular compartments. (B) Simplified overview of endosymbiont-containing Novymonas esmeraldas.
Fig 2.
Trypanosomatid signals employed for protein targeting, with accession identity specified in cases of singular examples and acronyms bolded at first appearance.
Trypanosomatid species is clarified and specified for protein representatives outside of Trypanosoma brucei.
Fig 3.
Overview of major protein targeting pathways in Trypanosoma brucei (unless stated otherwise).
(A) Secretory pathway with relevant organelles of endoplasmic reticulum (ER), Golgi body, lysosomes, and plasma membrane. (B) Protein targeting across and into both mitochondrial membranes. (C) Targeting mediated by PEX proteins in glycosomes, employed on proteins containing PTS1 and PTS2 targeting signals as well as peroxisomal membrane proteins (PMP). (D) Trafficking through the nuclear pore complex (NPC), with entry mediated via Nuclear localization signals (NLS) and Nucleolar targeting signals (NoLS) and exit via Nuclear exit signals (NES). (E) Flagellar protein trafficking, with retrograde (blue arrow) and anterograde direction (red arrow) indicated across the axoneme. (F) Endosymbiont-targeted TMP18e in Novymonas esmeraldas. Targeting signals on proteins are highlighted in red, with acronyms defined in Fig 2.