Fig 1.
Key milestones in the development of tecovirimat and its mechanism against poxviruses.
Fig 2.
Mechanism of tecovirimat action against Orthopoxvirus.
The upper panel illustrates the molecular mechanism by which tecovirimat interacts with F13. The lower panel depicts the stage affected by tecovirimat within the Orthopoxvirus life cycle. Tecovirimat binds to F13 and promotes the formation of F13 homodimers, thereby inhibiting viral wrapping. The area where tecovirimat exerts its effect is highlighted in orange.