Fig 1.
The schematic representations of HIV-1 Gag domains and assembly process.
(A) Gag domains and key basic residues or basic residue clusters discussed in this review. Upon cleavage of Pr55Gag, individual domains give rise to mature Gag proteins, MA, CA, p2 (SP1), NC, p1 (SP2), and p6. NTD, N-terminal domain; CTD, C-terminal domain; ZF, zinc finger. (B) Interactions between basic residues in Gag and polyanions play important roles at different steps of virus particle formation and post-assembly processes. In some cases, the basic residues in Gag and the polyanions switch their interaction partners through the transitions from one step to another. PI(4,5)P2, phosphatidylinositol (4,5) bisphosphate; IP6, inositol hexakisphosphate; vRNA, viral genomic RNA.