Fig 1.
Model of actin in prion formation.
(A) PrLD containing endocytic coat proteins (such as Sla1, Ede2, and Ent1, shown as shapes) are suggested to form condensates that mediate the initiation of endocytosis. In addition, the Lsb2 endocytic coat protein forms metastable prions (shown in yellow), although it is unclear whether these metastable prions are associated with the endocytic condensate. The presence of condensates or metastable prions may recruit the prion domain of Sup35 (orange protein with prion domain shown as black line) to nucleate the formation of pre-prion seeds. (B) Actin cable networks (red) have been shown to play a role in the retention of unhealthy organelles or damaged proteins in the mother cell. Recent work has shown that the disruption of actin cables is associated with increased [PSI+] induction frequencies, which may facilitate enhanced transmission of propagons. Therefore, the implications of this study suggest that normal actin cables may play an important role in restricting propagon transmission to daughter cells.