Fig 1.
Chemical structures of FKBP12 ligands and crystal structure of FKBP12-FK506 inhibiting target calcineurin.
Chemical structures include rapamycin, FK506, FK520, meridamycin, WDB002, and antascomicin B. FK506 chemical structure is shown with FKBP12 binding domain highlighted in red and the calcineurin binding domain highlighted in blue. In the center is the crystal structure of Cryptococcus neoformans calcineurin and FKBP12 bound to natural product FK506 (Calcineurin A subunit colored dark blue, calcineurin B subunit colored light blue, FKBP12 colored dark red, and FK506 colored by atom). Crystal structure adapted from “Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents” (PDB 6TZ8) [3]. The original figure was published under CC BY 4.0 giving freedom to share and adapt figures from the source listed above.