Fig 1.
Flow diagram of patient inclusion.
Number of participants included in the study analysis. Excluded participants are indicated in lateral text boxes.
Table 1.
Participant demographics, vaccination status and viral characteristics.
Table 2.
Viral shedding outcomes for adult participants, by vaccination status.
Fig 2.
Dynamics of viral RNA decay, by vaccination status.
Mixed effects model predicting mean viral RNA load of N (A) and E (B) targets longitudinally in unvaccinated and vaccinated participants. The analysis was done from the maximum detected viral RNA load of each participant (day 0) over seven days. Linear slopes were fitted to the data from vaccinated and unvaccinated groups and the P value for the significance of the interaction between vaccination status and time is shown. The color gradient of dots along the x axis represents increased proportions of specimens with no detectable viral RNA.
Fig 3.
Proportion of specimens with infectious virus over the infectious period.
Correlation between the maximum viral RNA level (N copies/ml) for a given participant and the infectious viral titer of that same nasal specimen. Pearson’s correlation was used to assess the strength of the correlation. B) The proportion of nasal samples with infectious virus in unvaccinated and vaccinated participants by day post symptom onset. The number of specimens assessed at each time point is indicated in the lower box. The last column is a sum of all samples assessed from day 15 onwards. Logistic regression analysis spanning days 1–5 and 6–12 was done to assess statistically significant differences between groups.