Fig 1.
Viral proteins target the Mediator complex to control viral and host gene expression.
Viral proteins known to bind to or associate with Mediator proteins in the tail, middle, and head and CDK modules are depicted. Ad, adenovirus E1A; BUNV, Bunyamwera virus NSs; CDK8, cyclin-dependent kinase 8; DENV, dengue virus NS5; HPV, human papilloma virus E7; HSV, herpes simplex virus VP16; KSHV, Kaposi sarcoma–associated herpesvirus Lana-1; RSV, respiratory syncytial virus NS1; RV-cyclin, retroviral cyclin; VZV, varicella zoster virus IE62; WDSV, Walleye dermal sarcoma virus. Created with BioRender.com.