Fig 1.
Current challenges and development of polyvalent vaccines.
(A) Current potential challenges to development of polyvalent vaccine preparations. (B) Development and licensing of polyvalent vaccines in the United States. Combination vaccines are not reviewed here. Different colors indicate vaccines against the same pathogen. Blue, Streptococcus pneumoniae (polysaccharide vaccine and conjugate vaccine); red, poliovirus (inactivated vaccine and oral, live-attenuated vaccine); purple, Neissaeria meningitides (meningococcal vaccine: polysaccharide and conjugate vaccine); yellow, rotavirus (live attenuated); green, HPV, VLP; gray, adenovirus; white, influenza (inactivated and live-attenuated vaccines). Not all influenza vaccines are included. HPV, human papillomavirus; QC, quality control; VLP, viruslike particle.