Fig 1.
Additional cell fates after viral infection and roles for survivor cells.
Cells that are infected with a cytopathic virus that normally causes cell lysis (blue) can sometimes intrinsically eliminate the virus and become a “survivor” cell (orange). These survivor cells have been shown to be important for contributing to inflammation and altering the response to secondary infection. Previously proposed or possible additional functions of survivor cells include (among others): serving as a long-term source of viral protein to antigen-presenting cells (APCs) and/or maintaining critical tissue structures and functions.