Table 1.
Infectious prions and prion-like proteins.
Fig 1.
Electron cryomicroscopy analysis of infectious prion protein amyloid fibrils.
(A) Section of a cryo electron micrograph showing prion fibrils lacking the glycosylphosphatidylinositol (GPI) anchor. A single isolated and twisted fibril used for the 3-D reconstruction is enclosed by a black box. (B) Close-up view of the isolated prion fibril. (C) Reprojected image of the 3-D fibril map for comparison with the unprocessed image (B). (D) 3-D reconstruction of the GPI-anchorless prion fibril. (E) Cross section of the reconstructed fibril showing two distinct protofilaments. (F) Contoured density maps of the cross section with lines contoured at increasing levels of 0.125 σ. (G) Cartoon depicting the proposed configuration of the polypeptide chains in the prion fibril. Please note that this is not an atomistic model. (H) Close-up view of the possible ß-sheet stacking in a four-rung ß-solenoid architecture for illustration purposes only. Different colors represent different ß-solenoid rungs. Characteristic distances of the four-rung ß-solenoid architecture are labeled. Figure adapted from [10].