Fig 1.
Replication cycle of poliovirus, annotated with references to key findings during the past 65 years.
Abbreviations and symbols: 3D, three-dimensional; receptor proteins (grey cylinders spanning plasma membrane); RNA, ribonucleic acid; VPg, viral protein, genome-linked (red oval); ribosomes (medium blue oval shapes bound to viral RNA); + strand RNA, positive-sense genomic RNA (blue horizontal or wavy line);—strand RNA, negative-sense antigenomic RNA (red horizontal or wavy line); 3Dpol, viral RNA-dependent RNA polymerase (pink shapes); membranous vesicles (light blue oval shapes); Nups, nucleoporins (orange, oblong oval shapes).