Figure 1.
Environmental cues sensed by C. albicans.
(A) Schematic representation of how C. albicans morphology and biofilm formation is regulated by quorum sensing and signaling with other microbial species. (B) Farnesol and 3-oxo-C(12)-homoserine lactone both act on the Ras1 pathway to inhibit the yeast-to-hyphal transition by inhibiting Cyr1 and cAMP signaling.
Figure 2.
C. albicans white and opaque cells respond differently to pheromone.
(A) The transcriptional network regulating formation of the opaque cell state (left) and white cell state (right) in C. albicans. Arrows indicate binding of a transcription factor to the promoter of another transcription factor, as determined by Hernday and coworkers [19]. (B) Schematic of the differential response of C. albicans white and opaque cells to pheromone. Pheromones induce mating responses in opaque cells but biofilm formation in white cells.