Table 1.
Summary of TB association genetic studies of NRAMP1/SLC11A1, including TB diagnostic criteria, characterization of controls, and whether there was an association with any SNP in the gene.
Figure 1.
Impact of variation in linkage disequilibrium (LD) in detection of disease risk alleles.
For all three scenarios, D is the underlying disease risk allele. (A) There is strong LD between D and marker #1 (M1), and weak LD between D and M2. In this situation, association will be detected with M1, depending on study power based on sample size, strength of genetic effect, and minor allele frequencies. (B) There is no LD between M1 and D but strong LD between M2 and D. Here, association will be detected only with M2 (again, depending on power). (C) There is weak LD throughout the region. Association will likely not be detected.
Figure 2.
Linkage disequilibrium (LD) of the NRAMP1 gene for HapMap reference populations.
Yoruba (YRI), Maasai (MKK), Han Chinese (CHN), Utah Caucasians (CEU), and African Americans (ASW) are shown. The strength of LD is illustrated using the color scale shown in the figure key.