Table 1.
Determinants of Pathogenicity in the Sialic Acid Binding Pocket of Vp1
Figure 1.
Effects of Single Amino Acid Replacements in Vp1 on Replication and Spread in Neonatally Infected C3H/BiDa Mice
Whole mouse section hybridizations were carried out one week after virus inoculation (dose of 2 − 5 × 107 pfu/animal). See Table 1 and text. Reprinted from [10] with permission from Academic Press.
Table 2.
Serological Tests for Py Virus in Feral Mice
Figure 2.
Origin Regions of Three Standard Polyoma Laboratory Strains and Eight Polyoma Isolates from Feral Mice
Amino acids at positions 91 and 296 of Vp1 are shown on the left. The origin regions on the right are denoted schematically as horizontal lines representing the sequences between the start sites for Vp2 (CAT←) and the T antigens (ATG→). The PTA sequence on the top is used as a reference. The bidirectional replication origin (← →) and the PvuII and Bgl1 restriction sites are shown as points of reference. The 40–base pair duplication at the Bgl1 sites in PTA is designated with shaded rectangles. Insertions and deletions are denoted by open boxes and open triangles, respectively, along with the number of base pairs.
Table 3.
Tumor Induction by Laboratory Strains and Feral Mouse Isolates of Polyomavirus