Figure 1.
Decline and Stable Persistence of Plasma HIV-1 RNA in Patients Suppressed on Antiretroviral Therapy
Plasma from patients initiating antiretroviral therapy with stavudine + lamivudine + efavirenz (patients A and B) or stavudine + lamivudine + indinavir + nevirapine (patient C) was assayed by bDNA (diamonds) and SCA (squares). Levels of virus above the limit of detection for each assay are shown by filled symbols; levels below this limit are shown by hollow symbols plotted at the assay limit.
Figure 2.
Distribution of Plasma HIV-1 RNA Levels in Patients with Persistently Suppressed Viremia (HIV-1 RNA <50 Copies/ml from Week 24 to 60) on Standard Antiretroviral Therapy
Week 60 viral RNA levels for M98–863 patients on LPV/r- (blue) or NFV-containing (red) regimens were determined by SCA. The percentile of patients in each group with a given RNA level is presented. SCA determinations for patients on NNRTI- containing regimens (n = 28) for >1 y are included (green). The inset shows the mean and median log10 RNA levels for each group.
Figure 3.
Correlation between Pretherapy and On-Therapy Viral RNA Levels
Pretherapy and week 60 SCA values were determined for 130 patients from both the NFV and LPV/r arms in M98–863. Correlation coefficients for patients taking LPV/r and NFV regimens were similar.
Figure 4.
HIV-1 RNA Levels Over 50 wk of Suppressive Antiretroviral Therapy
Plasma samples from patients in both arms of the M98–863 trial with viremia suppressed to <50 copies/ml during weeks 60–110 were subjected to SCA analysis. HIV-1 RNA levels for each patient are presented here as a function of weeks on therapy.