Physiologic recovery of Mycobacterium tuberculosis from drug injury: A molecular study of post antibiotic effect in vitro and in vivo
Fig 5
Overview of recovery in murine samples.
(a) Change in CFU and (b) RS ratio of samples during the PAE phase of recovery. Each dot represents one sample, and lines connect the median values across timepoints for 2-week treatment (blue) and 4-week treatment (pink) groups. (c) Hierarchical clustering of genes differentially expressed over PAE phase (N = 3,017 genes). The heatmap shows the batch-adjusted, VST-normalized, scaled gene expression averaged across samples. Clustering identified four broad patterns. Dot plots show the average expression for each cluster across time points. Each point represents an individual sample from 2-week treatment (blue) or 4-week treatment (pink) group. Horizontal lines indicate average values. Values are centered around the average value for the pre-treated samples so that points above and below zero represent upregulation and downregulation relative to pre-treatment, respectively.