Discovery of a novel Betacoronavirus 1, cpCoV, in goats in China: The new risk of cross-species transmission
Fig 5
Pathogenicity experiments in cpCoV-infected calves.
The animals were intranasally inoculated with 2 × 106 TCID50 virus. The diarrhea index was evaluated in the four groups. Calves in the CC-7 and CC-14 groups showed apparent diarrhea (A) and an elevated temperature (B) compared with the NC groups. CpCoV viral RNA shedding was detected in rectal (C), nasal (D), and throat (E) swabs. Viral load was detected in almost all organs of calves in CC-7 and CC-14 groups (F). Histopathological examination of cpCoV-infected calves. Pathological changes in calves in the CC-7 group were mainly in the intestine, with severe disintegration and shedding of the intestinal villi in the duodenum (G and H), ileum (I and J), jejunum (K and L), cecum (M and N), colon (O and P), and rectum (Q and R).