Cytomegalovirus inhibitors of programmed cell death restrict antigen cross-presentation in the priming of antiviral CD8 T cells
Fig 5
Viral genome-wide screening of the viral antigen-specific CD8 T-cell response in dependence on apoptosis.
A viral genome-spanning ORF library of expression plasmids was used to test the overall CD8 T-cell response determined for the spleen on day 7 after intra-plantar infection of BALB/c mice (cohorts of 7 mice) with the viruses indicated. Signals represent frequencies of CD8 T cells activated to express intracellular IFNγ after stimulation with antigenic transfectants. For more prominent signals, the corresponding ORF is named.