Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir
Fig 5
Barcode assessment post rebound.
Rebound kinetics and barcodes for each rebounding RM are presented based on the post-infection day ART was initiated with the rebound pVL of each RM shown on the left and the relative barcode proportion at peak rebound shown on the right (A-F). Representative (d5 ART group) of barcode comparisons across time post rebound and compared to pre-ART population (G). LOD is determined by viral input levels and is shown as elevated x-axis levels. Groups are color-coded based on days post infection until ART: d3 (blue), d4 (red), d5 (green), d6 (purple), d7 (orange), d9 (black) and d12 (brown).