RNase L activation in the cytoplasm induces aberrant processing of mRNAs in the nucleus
Fig 5
RNase L activation results in alterations to host RNA processing.
(A) Distribution of intron/exon ratios of host RNAs in WT and RL-KO cells following mock or poly(I:C) lipofection. (B) IGV traces mapping to an example gene. Intron retention and DoG formation is highlighted in WT cells following poly(I:C) lipofection. (C) Distribution of DoG1-5000bp/exon ratios of host RNAs in WT and RL-KO cells following mock or poly(I:C) lipofection.