HLA-A*11:01-restricted CD8+ T cell immunity against influenza A and influenza B viruses in Indigenous and non-Indigenous people
Fig 5
CD8+ T cell responses to novel IBV epitopes.
(A) Frequency of IFN-γ+CD8+ T cells after stimulation with individual IBV peptide pools. Median and IQR are shown (n = 10). Representative FACS plots are shown for CD8+ T cell responses from one donor towards peptide pool 1–3 and the negative control. (B) Frequency of IFN-γ+CD8+ T cells in response to stimulation with individual peptides from Pool 1. Median and IQR are shown (n = 2–9). A representative FACS plot of one donor with a CD8+ T cell response to NP511-520 or NS1186-195. (C) Frequency of IFN-γ+CD8+ T cells in response to stimulation with individual peptides from Pool 2. Median and IQR are shown (n = 2–9). Representative FACS plot of one donor with a CD8+ T cell response to M141-49. (D) Proportions of CD8+ T cells with 1–4 functions after stimulation with NP511-520, NS1186-195 or M141-49 (n = 8 or 9, respectively). A permutations test was used to determine statistical significance. (A-C) Friedman test with Dunn’s correction for multiple comparisons was used to determine statistical significance.