Fungicide effects on human fungal pathogens: Cross-resistance to medical drugs and beyond
Fig 3
Fungicide exposure effects on Cryptococcus spp.
(a) Exposure to fungicides can select cross-resistance to clinical azoles especially through overexpression of efflux pumps (MDR11 and AFR1) and ERG11 genes, the azole target. (b) Different fungicides also can induce important alterations in the cell morphophysiology of Cryptococcus cells that may be related to virulence.