A new paradigm for leprosy diagnosis based on host gene expression
Fig 5
Differentially expressed genes from multibacillary (MB) vs. paucibacillary (PB) leprosy lesions.
(A) Volcano plot showing DEG from the MB vs. PB comparison, where blue points are DE with |log2FC| ≥1 and FDR < 0.1. (B) Scatter plots with the 161 DEG common between this study and Belone et al. (24) microarray for the same comparison. Red and green dashed lines indicate log2FC of -1 and 1, respectively. Blue points are genes with the same modulation signal and red indicates discordancy. Rho, Spearman’s rank correlation coefficient. CCC, Lin’s concordance correlation coefficient. Venn diagram on the right displays the number of DEG in each study according to FDR < 0.01. (C) Biological processes from GO enriched from up-regulated and (D) down-regulated DEG. FDR, false discovery rate.