Co-chaperone involvement in knob biogenesis implicates host-derived chaperones in malaria virulence
Fig 7
Proposed model for eKnob formation and structure.
In opposition to normal knob formation in the CS2 cell line (left) runaway extension of the spiral underlying eKnobs in ΔPFA could drive their elongation (right). KAHRP is still present and associated with the inner lumen of eKnobs, PfEMP1 anchored in the eKnobs is incorrectly presented and has thus a reduced cytoadherence capacity.