Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity had no antiviral effects but moderately reduced lung inflammation
Fig 5
Effect of convalescent plasma on infectious virus titers in BAL and lung tissues.
(A) Infectious virus titers in BAL supernatant (expressed as plaque-forming units (PFU) per ml) did not show any difference between the 2 study groups for any of the time points of BAL collection. Lines indicate median values. The dotted line indicates the limit of detection (LOD). (B) Infectious virus titers in lung tissues. For each animal, two snapfrozen lung specimens (one sample per left and right caudal lung lobe) were tested for infectious virus. The only 3 samples with detectable virus were all right caudal lobe samples of 3 control animals, with detection of 1 plaque; taking the dilution factor of the assay and weight of the original tissue specimen into account, this was then expressed as PFU per mg lung tissue. Comparison of both groups revealed a significant difference (p = 0.028, Mann-Whitney test).