The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamsters
Fig 2
Lung histopathology in hamsters after intranasal inoculation with B.1.429 is more acute and prolonged than in hamsters inoculated with B.1 (614G) and B.1.427.
A, F, K) Sub-gross histology of normal lungs from uninfected hamsters. Top row: Sub-gross histology of B.1 (614G) infection after B) 2 days PI, C) 4 days PI, D) 6 days PI, E) 10 days PI. Middle row: Sub-gross histology of B.1.427 infection after G) 2 days PI, H) 4 days PI, I) 6 days PI, J) 10 days PI. Bottom row: Sub-gross histology of B.1.429 infection after L) 2 days PI, M) 4 days PI, N) 6 days PI, O) 10 days PI. Asterisks = foci of inflammation, necrosis and/or hemorrhage. Hematoxylin and eosin stain. Original magnification: 1x. Scale bars equal 1 mm.