Human parainfluenza virus type 1 regulates cholesterol biosynthesis and establishes quiescent infection in human airway cells
Fig 5
Downregulation of genes involved in cholesterol biogenesis in hPIV1 infected cells.
(A) Top 10 GO terms of DEGs downregulated in hPIV1 infected cells compared to hPIV3. (B) Fold change in expression of genes involved in cholesterol biosynthesis in hPIV1 or hPIV3 infected cells compared to mock infected cells. (C) Total cellular cholesterol in A549 cells infected with hPIV1 or hPIV3 at an MOI of 5. (n = 3) *P≤0.05, **P≤0.01. (D) Total cellular cholesterol in A549 cells infected with various doses of hPIV1. (n = 3) *P≤0.05, **P≤0.01 ***P≤0.001.