COVID-19 virtual patient cohort suggests immune mechanisms driving disease outcomes
Fig 7
Effects of neutrophil, monocyte, and macrophage knockout on mild disease courses.
We performed in silico knockout experiments in the mild disease scenario (Fig 4, blue solid lines) by considering complete monocyte knockout (i.e. no monocyte recruitment and M(0) = 0; dark pink dash-dot line), complete macrophage knockout (i.e. not inflammatory macrophage creation via antigen stimulation or monocyte differentiation; light pink dotted line) and complete neutrophil knockout (i.e. no neutrophil recruitment and N(0) = 0; pink dashed line). Dynamics of the in silico knockout are plotted for the A) viral load, B) uninfected cells, C) inflammatory macrophages, D) neutrophils, E) CD8+ T cells relative to uninfected cells and F) unbound IL-6.