COVID-19 virtual patient cohort suggests immune mechanisms driving disease outcomes
Fig 6
Moderate increases to viral infectivity are not predicted to significantly impact immunological outcomes.
A range of viral infectivity rates (β) from 0% (base) to 50% increase were simulated. All other parameters were fixed to their value in S1 Table. The resulting model dynamics for viral load, inflammatory macrophages, CD8+ T cells, unbound IL-6 and unbound IFN were compared, and no significant changes in kinetics were predicted.