CryoEM structure of the Nipah virus nucleocapsid assembly
Fig 5
Clam-shaped nucleocapsid assembly.
(A) Model of the clam-shaped nucleocapsid assembly, presented as a molecular surface with subunits coloured as in Fig 2A, showing the interaction between two opposing, top and bottom N protein spirals, with one of the protomers shown as ribbon. (B) The clam-shaped interaction is primarily mediated by protein loops from the N-terminal Ncore domain. Putative residues involved in the interaction between the two halves of the shell are indicated. (C) Alignment of the three interacting loop regions highlighted in (B) for N proteins from several Paramyxoviruses, with glycine, proline and surrounding conserved residues highlighted using the ClustalX colour scheme.