pMGF505-7R determines pathogenicity of African swine fever virus infection by inhibiting IL-1β and type I IFN production
Fig 9
Deletion of MGF505-7R attenuates ASFV virulence in pigs.
(A-C) The rectal temperature measurements (A) and survival rates (B) for the different groups of pigs unchallenged (Ctrl, n = 4), or challenged with 103 HAD50 of parental ASFV-WT (WT, n = 4), 103 HAD50 of ASFV-Δ7R (Δ7R, n = 7) or 105 HAD50 of ASFV-Δ7R (Δ7R, n = 7) were recorded daily till day 19 post challenge. At day 19, the surviving pigs were euthanized, and the blood and tissues including the heart, lung, spleen, tonsil, thymus and five lymph nodes (intestinal lymph node, inguinal lymph node, submaxillary lymph node, bronchial lymph node, and gastrohepatic lymph node) were collected from all pigs for viral DNA quantification by qPCR (C).