Evolutionary plasticity of SH3 domain binding by Nef proteins of the HIV-1/SIVcpz lentiviral lineage
Fig 9
Putative cross-species transmission and evolution of R-clamp categories.
The pie charts on the left illustrate the relative fraction of each R-clamp category in SIVcpz, SIVgor and HIV-1 groups M, N, O and P. Putative cross-species transmission events are indicated by colored arrows. The lower part of the figure shows a phylogenetic analysis of selected primate lentiviral Nefs is shown. Inferred most recent common ancestors are indicated by stars. In both images, R-clamp categories I, II, III, and IV are shown in blue, yellow, grey and orange, respectively.