Nitrofurans: Revival of an “old” drug class in the fight against antibiotic resistance
Fig 2
New nitrofuran molecules IITR06144 and compound 17 (A) and a nitroaromatic pharmacophore 2-nitrothiophene-3-sulfonyl fluoride (B). Red arrows indicate the amide bonds of nitrofurantoin that are hypothetically hydrolyzed by the CTX-M-14 triple mutant variant.