Structurally distinct external solvent-exposed domains drive replication of major human prions
Fig 5
Relative protection factor of MM1, MM2, and VV2 sCJD prions. The protection factor for individual residues was calculated from the modification rate of •OH modification of amino acid side chains in α-helical monomeric recHuPrP divided by the modification rate of the same residues in (a) MM1, (b) MM2, and (c) VV2 prions; the different range of amino acid protection is indicated by the color scale. (d) Comparison of protection factors in three strains of sCJD prions.