The ultrastructure of infectious L-type bovine spongiform encephalopathy prions constrains molecular models
Fig 2
Negative stain electron micrographs of purified L-type BSE samples showing heterogeneous morphologies.
Representative electron micrographs of (A) large PrP 27–30 aggregates, (B) isolated forms of both single (arrowheads) and double (arrow) protofilament fibrils, and (C) 2D crystals along with amyloid fibrils. Grids stained with 2% uranyl acetate. Scale bar = 100 nm.