Extensive C->U transition biases in the genomes of a wide range of mammalian RNA viruses; potential associations with transcriptional mutations, damage- or host-mediated editing of viral RNA
Fig 9
Proportionate excess of C->U over U->C transitions in phylogenetically informative and non-informative sites.
Excess C->U mutations (number of sites with majority C->U transition–sites with U->C) expressed as a proportion of all variable sites in genome alignments of viruses showing C->/U->C asymmetry. Proportions were normalised by mononucleotide base frequencies. Separate proportions were calculated by AI band, representing sites that were phylogenetic informative (low AI values) through to uninformative (high AI values).