Resistance to lethal ectromelia virus infection requires Type I interferon receptor in natural killer cells and monocytes but not in adaptive immune or parenchymal cells
Fig 2
IFNAR in hematopoietic cells is necessary for efficient T cell responses to ECTV.
BMC mice were infected as in Fig 1A, and spleens were harvested at 7 dpi. (A) Representative flow cytometry plots showing the frequency of CD44+ and GzmB+ cells on gated CD8 T cells (NK1.1-TCRβ+CD8+) and on CD4 T cells (NK1.1-TCRβ+CD4+). (B) Percentages and numbers of cytotoxic GzmB+ CD8 and CD4 T cells. (C) Percentages and numbers of antigen experienced CD44+ CD8 and CD4 T cells. Data are represented as mean ± SEM from three pooled independent experiments (N = 11 per group, N = 3 for Ifnar1-/-→ Ifnar1-/-, multiple comparison ANOVA with Tukey correction).