Extensive activation, tissue trafficking, turnover and functional impairment of NK cells in COVID-19 patients at disease onset associates with subsequent disease severity
Fig 5
Ordinal logistic fit of variables with subsequent clinical trajectory according to modified WHO classification.
Panel A: Logistic profiler for the disease course for age and lymphocyte n° at admission according to subsequent disease trajectory. Logistic fit of the model is indicated. The vertical dotted line for given X variables shows a representative current value (red number). Horizontal dotted lines show the current predicted value for the displayed values of the X variables. Panel B: Logistic profiler for disease course according to the proportion of CD34+DNAMbrightCXCR4+ cells, the proportion of NKG2D+ and of NKG2C+ NK cells. Logistic fit of the model is indicated. The vertical dotted line for given X variables shows a representative current value (red number). Horizontal dotted lines show the current predicted value for the displayed values of the X variables. Panel C: Logistic profiler for disease course according to the proportion of CD103+ NK cells and of CD49+CD103+ NK cells. Logistic fit of the model is indicated. The vertical dotted line for given X variables shows a representative current value (red number). Horizontal dotted lines show the current predicted value for the displayed values of the X variables.