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Therapeutic targeting of measles virus polymerase with ERDRP-0519 suppresses all RNA synthesis activity

Table 2

EC₅₀ concentrations against MeV L of resistance mutations induced by viral adaptation to ERDRP-0519 and GHP-88309, respectively.

Binding kinetics (K_D) between MeV L₁₇₀₈ or MeV L₁₇₀₈ harboring resistance mutations and ERDRP-0519 or GHP-88309 are shown.

doi: https://doi.org/10.1371/journal.ppat.1009371.t002