Therapeutic targeting of measles virus polymerase with ERDRP-0519 suppresses all RNA synthesis activity
Fig 2
Target binding affinity of ERDRP-0519.
A) SDS-PAGE of purified full-length MeV L, MeV L1708 [36], and RSV L used for BLI studies. B-G) BLI of ERDRP-0519 and purified standard (WT) MeV L (B), MeV L1708 (C), RSV L (D) and MeV L1708 harboring selected ERDRP-0519 resistance mutations (E-G). Similar binding kinetics were observed for full-length MeV L and MeV L1708. KD values and goodness of fit are shown for each construct.