SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development
Fig 2
The 24-hour intracellular NTP concentration of adenosine antiviral drug leads (MK-0608, Gilead Sciences remdesivir prodrug GS-5734, and Gilead Sciences remdesivir parent nucleoside GS-441524) after incubation at 1 μM illustrates the apparent deficiency of Vero E6 cells with regard to conversion to the active triphosphate form as compared to other cell lines studied. NTP, nucleoside triphosphate.