Human splice factors contribute to latent HIV infection in primary cell models and blood CD4+ T cells from ART-treated individuals
Fig 2
The Wild-type model: HIV latency is regulated by blocks to initiation, multiple splicing, and possibly elongation.
(A) Diagram of the model, (B) total HIV DNA, (C) level of HIV transcripts per million cells, (D) level of HIV transcripts per provirus, (E) progression through HIV transcription stages. Individual values per donor (dots), and median and range (bars) are shown. Unstimulated cells (days 10 and 12 post-infection) are shown in light colors and stimulated cells (day 12) in dark color.