The narrow-spectrum anthelmintic oxantel is a potent agonist of a novel acetylcholine receptor subtype in whipworms
Fig 3
Effect of the ancillary protein Resistance-to-cholinesterase (RIC-3) from Xenopus laevis (Xla-RIC-3), Ascaris suum (Asu-RIC-3), Haemonchus contortus isoform 1 (Hco-RIC-3.1), Caenorhabditis elegans (Cel-RIC-3) on the functional expression of the ACR-16-like nAChR from Trichuris suis (Tsu-ACR-16-like receptor).
Representative sample traces of inward current in response to 100 μM ACh are shown together with a scatter dot plot presenting the relative currents (mean ± SEM). Non-injected oocytes and oocytes injected with Tsu-acr-16-like- or Asu-ric-3 cRNA alone did not respond to 100 μM ACh which was significantly different from oocytes co-injected with Tsu-acr-16-like and either of the tested ric-3 cRNAs (**P < 0.01). The relative currents of oocytes co-injected with Tsu-acr-16-like and either of the tested ric-3 cRNAs were not significantly different (P > 0.9) as indicated, Kruskal-Walis Test.