The narrow-spectrum anthelmintic oxantel is a potent agonist of a novel acetylcholine receptor subtype in whipworms
Fig 2
Amino acid alignment of ACR-16-(like) and ACR-19 subunit sequences from the Clade I parasitic nematodes Trichuris suis, T. trichiura, T. muris, Trichinella spiralis and Caenorhabditis elegans.
Predicted signal peptide sequences are shaded in grey, the Cys-loop, the transmembrane regions (TM1-TM4), and the YxCC motif that characterize an α-subunit are indicated above the sequences. Conserved amino acids between ACR-16-(like) and ACR-19 sequences (dark blue), conserved amino acids between all ACR-16-(like) sequences (red), conserved amino acid between all ACR-19 sequences (light green), conserved amino acid between ACR-16-like sequences of Clade I parasitic nematodes and ACR-19 of C. elegans (light blue).