SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts
Fig 2
PET/CT imaging of SARS-CoV-2-infected AGM.
(A) and (B) Region-of-interest analysis on PET images of animals infected with SARS-CoV-2. (A) Measurement of total lung inflammation via FDG uptake over time. (B) Measurement of average lymph node inflammation over time. Aerosol (closed symbols/solid lines; n = 3); multi-route mucosal (open symbols/dashed lines; n = 2). Animal A2 is not included in (A) and (B) because only CT scans were performed. (C) For AGM A4 (aerosol), only CT scan was obtained pre-infection; PET/CT at was obtained at 4 dpi and 11 dpi. (D) For AGM M1 (multi-route mucosal), only CT scan was obtained pre-infection; PET/CT at was obtained at 4 dpi and 11 dpi.. Pulmonary infection (yellow arrows); thoracic lymph nodes (green arrows). Cyan arrow highlights new focal area of disease visible on 11 dpi. PET color scale is from 0–15 SUV.